campbl15 - features and heart defects – Most...

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Lab Exam
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Chromosomal Basis of Inheritance
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Independent Assortment
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2-Locus Test Cross Special dihybrid with Recessive “Blank Slate” Parental Types Parental Types Recombinant Types Expected ” assumes Independent Assortment
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Deviation from Expected Special dihybrid with Recessive “Blank Slate” Parental Types Parental Types Recombinant Types
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Linkage
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Frequency of Recombination
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Constructing Genetic Maps
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Gender Determination
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Sex-Linkage (in mammals)
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Sex-Linkage Inheritance Patterns Dominant or Recessive Sex-Linked Inheritance?
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Hemophilia in the Russian Royal Family
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Barr Bodies & Dosage Compensation
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Nondisjuction
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Common Aneuploidies Polyploidies (e.g., in plants) are actually less serious than one too many (or one too few) autosomes Most abnormalities in numbers of autosomes ( anueploidies ) are very serious or fatal due to gene dosage imbalances The fewer genes unbalanced, the less serious the condition Down’s syndrome : Caused by a trisomy of chromosome number 21 (1 in 700 births)—mental retardation, mongoloid
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Unformatted text preview: features, and heart defects – Most abnormalities of sex chromosomes do not affect survival • Klinefelter Syndrome : Males with an extra X chromosome (XXY) (1 in 1000 male births) • Turner Syndrome : Females missing one X chromosome (XO) (1 in 2500 female births) Down Syndrome XO – Turner Syndrome Turner Syndrome (XO), Incidence: 1 in 2500 female births XXY – Klinefelter Syndrome Klinefelter Syndrome (XXY), Incidence: 1:1000 male births Super Male Chromosomal Rearrangements Translocation Genomic Imprinting Cytoplasmic Inheritance Link to Next Presentation Acknowledgements http://207.233.44.253/wms/reynolmj/lifesciences/lecturenote/bio3/Chap09.ppt http://www.ucl.ac.uk/~ucbhjow/medicine/RGD_lectures/modes_of_inheritance.ppt http://www.bbchs.k12.il.us/Teacher_Pages/Hammond/Powerpoint/Chapter_14.ppt Sex-Linkage (in Drosophila ) Down Syndrome...
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campbl15 - features and heart defects – Most...

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