black13 - Chemotherapy Chemotherapy is the use of chemical...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Chemotherapy Chemotherapy is the use of chemical substances (drugs) to treat disease To be effective, a drug must combat the disease to a greater extent than that drug poisons the host ( Selective Toxicity ) Symptoms of host poisoning we call side effects An Antibiotic is "a chemical substance produced by microorganisms which has the capacity to inhibit the growth of bacteria and even destroy bacteria and other microorganisms in dilute solution." Complexity of Antimicrobial Therapy Antimicrobic Drug (=antibiotic or synthetic drug) Drug Delivery Problems Oral (destruction/poor uptake), Intravenous or Intramuscular (inconvenient), Topical , Poor Tissue Uptake , Injection into Body Cavity Wrong Drug Wrong Spectrum of Activity (informed best guess), Few Targets on Pathogen (fungi, protozoa, viruses) Drug Retention Problems Elimination from Host , Inactivation by Host Side Effects Toxicity to Host , Allergic Reaction , Normal Flora Disruption (superinfection) Antimicrobial Administration Selective Toxcity & Successful Delivery Complexity of Antimicrobial Therapy Toxins Exotoxins , Endotoxins (in Gram-negative septicemia antibiotic treatment can make situation even worse) Development of Resistance Evasion , Mutation-Mediated , Acquired (R plasmids) Prevention of Growth Bactericidal , Bacteriostatic , Host Defenses (elimination of pathogen from body) Prevent Resistance by Using Only as Necessary , At sufficiently high doses for sufficiently long periods , In Combination Selective Toxcity & Successful Delivery Complexity of Antimicrobial Therapy Distinguishing Antibiotics Antibiotics differ in terms of their chemical structure the organism they are or were isolated from their site of action in bacterial cells bacteriostasis versus bacteriostatic the spectrum of bacteria they are active against the degree to which susceptible organisms are capable of evolving resistance toxicity to the host Distinguishing Antibiotics Antibiotics differ in terms of their chemical structure the organism they are or were isolated from their site of action in bacterial cells bacteriostasis versus bacteriostatic the spectrum of bacteria they are active against the degree to which susceptible organisms are capable of evolving resistance toxicity to the host Distinguishing Antibiotics Antibiotics differ in terms of their chemical structure the organism they are or were isolated from their site of action in bacterial cells bacteriostasis versus bacteriostatic the spectrum of bacteria they are active against the degree to which susceptible organisms are capable of evolving resistance toxicity to the host Antibiotics Sources Distinguishing Antibiotics Antibiotics differ in terms of their chemical structure the organism they are or were isolated from their site of action in bacterial cells...
View Full Document

Page1 / 74

black13 - Chemotherapy Chemotherapy is the use of chemical...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online