nester17 - Chapter 17: Applications of Immune Responses...

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Chapter 17: Applications of Immune Responses
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Important Point:
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Smallpox Vaccination
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Oral (Sabin?) Vaccination
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Vaccination by Syringe
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“Immunization has had probably the greatest impact on human health of any medical procedure.” Passive immunization involves reception of antibodies but with no stimulation of B or T cells. Infants are subject to passive immunization, which is the acquisition of IgG and IgA from their mothers. As a consequence, they typically are resistant to a number of infectious diseases until they are 3 to 6 months of age (with delay depending in part on whether they are breast fed) . Passive immunity also occurs with administration of Antitoxin, Antiserum, Hyperimmune globulin. Active immunity, by contrast, involves the proliferation of B and T cell memory cells.
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Types of Immunity
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Attenuated vs. Inactive Vaccination “An attenuated vaccine is a weakened form of the disease- causing microorganism of virus that is generally unable to cause disease,” but is able to replicate. “An inactivated vaccine is unable to replicate, but retains the immunogenicity of the infectious agent or toxin.” “Whole Killed” is included in “Inactivated” Vaccine. “Live Attenuated” & “Attenuated” are synonymous.
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Inactivated Vaccines Inactivated vaccines typically don’t induce cell- mediated immunity plus require boosting to effect adequate B cell response. Inactivated Whole Agent Vaccines, a.k.a., Whole
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nester17 - Chapter 17: Applications of Immune Responses...

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