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Final 2009 - Name Points Prof K C Nicolaou Final Exam CHEM...

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1. Match the following names with the appropriate structure : ginkgolide B, amphotericin B, rapamycin, brevetoxin B, Taxol ® , palytoxin, calicheamicin γ 1 I , epothilone B, vancomycin, resiniferatoxin (20 points) Name:_________________________________ Points:_________________________________________ Prof. K. C. Nicolaou Final Exam CHEM 151 - Molecules that Changed the World March 19, 2009 UCSD, Department of Chemistry and Biochemistry
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2. Match each of the following medicines with the appropriate molecular structure and mechanism of action : Nexium ® , AZT (Retrovir ® ), Valium ® , Viagra ® , Prozac ® (15 points) Molecular Structure Mechanism of Action A . Inhibits phosphodiesterase type5 (PDE5), an enzyme that cleaves and inactivates the messenger cyclic quanosine monophosphate (cQMP) B . Binds to GABA receptors C . Inhibits serotonin re-uptake, leading to higher levels of the neurotransmitter in the synapse D . Inhibits the HIV enzyme reverse transcriptase E . Blocks the H /K –ATPase, an enzyme that pumps acid into the stomach Medical Indication I. antidepressant drug II. erectile dysfunction drug III. antianxiety drug IV. anti-ulcer drug V. anti-AIDS drug
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3. Name three (3) major
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