HW 2 - Problem Set #2 Cofactors 1. Serotonin is...

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Unformatted text preview: Problem Set #2 Cofactors 1. Serotonin is biosynthesized from the amino acid L-tryptophan. Following oxidation at the 5 position of the indole ring by tryptophan hydroxylase, serotonin is generated with the assistance of the pyridoxal-phosphate cofactor. Provide a reasonable mechanism for the following transformation. HO HO PLP O OH NH2 HN NH2 HN 2. Fumaric acid is formed oxidatively with the assistance of an enzyme cofactor. Of the cofactors reviewed in lecture, which is the most likely candidate for this conversion? Provide a reasonable mechanism for the following transformation using the cofactor that you have chosen. O O OH HO O OH HO O 3. In week 2’s assigned reading (Walsh et al.), the authors describe the catalytic activity of the RebF/RebH two ­component reductase/halogenase. They observed that in the presence of an air ­saturated solution, the reaction rate decreases significantly. Explain this observation. 4. As mentioned in lecture, what is nature’s equivalent to LiAlH4? ...
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