Midterm 2010

Midterm 2010 - Name: Page |1 ID#: _ Bioorganic and Natural...

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N a m e : P a g e | 1 ID#: _____________________________ Bioorganic and Natural Products Chemistry – CHEM 157/257 Spring 2010 May 4, 2010 Midterm Exam Where appropriate, please show all mechanisms in detail. When using extra sheets of paper in the back of this test, please indicate page numbers. Question 1: /17 Question 2: /8 Question 3: /25 Question 4: /25 Question 5: /25 ------------------------------------------------------------ Total /100
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N a m e : P a g e | 2 1. Enzyme-catalyzed reactions. (a) Draw a free energy diagram for a typical enzyme catalyzed reaction. In the diagram, indicate the following species: E+S, E+P, EP, ES, ES [10 points] . (b) Indicate the path for the uncatalyzed reaction and the location of S [2 point] . (c) A mutant of the enzyme binds the substrate tighter by several orders of magnitude. What is the effect of this mutation on catalytic rate if the binding to the transition state is unaffected?
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This note was uploaded on 06/02/2011 for the course CHEM 157 taught by Professor burkart during the Spring '07 term at UCSD.

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Midterm 2010 - Name: Page |1 ID#: _ Bioorganic and Natural...

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