4-27-11 Notes

4-27-11 Notes - Kidneys Mech of H+ secretion Mech of...

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Kidneys Mech of H + secretion Mech of bicarbonate reabs in proximal tubule Fig 20-21 Mech of secretion of hydrogen ions (2) 1) In glomerulus blood is filtered. Filtered fluid same conc. As plasma. In proximal tubule apical/luminal have lots of transporter All coupled with na. Driving force very large. Basolateral membrane have large na/k pumps 2) utilize ammonia to buffer hydrogen ions. Ammonia is toxic in the body. NH 3 + H + =NH 4 + fxn of porton sodium exchanger. Ammonia = ammonium allow secretion of Hydrogen ions In public restrooms when people don’t flush, urine smell = ammonia ‘cause urine has a lot of ammonium which when alkaline is reversible. Deamination of glutamine = alpha ketaglutarate (from citric acid cycle). Alpha ketaglutartae can go to bicarbonate Bircarbonate reabsorbed into interstitial fluid and peritubular capillaries
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4-27-11 Notes - Kidneys Mech of H+ secretion Mech of...

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