Lecture 24

Lecture 24 - Lecture 24 Protein Structure Eventually...

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Unformatted text preview: Lecture 24 Protein Structure Eventually everything the gene does in terms of the function of the cells comes from the sequence of polypeptides Proteins : Polymers of amino acids Structural differences: Length Amino acid sequences Length of disulfide bonds Structural function : All the protein information is encoded in the sequence of amino acids Functional classes: St ructural proteins : Determ ine shapes of cells Scaffold proteins : Bring other proteins together Enzymes : Catalyze chemical reactions Membrane t ransport proteins : Flow across cellular membrane Regulatory proteins : Act as signals, sensors and switches Motor proteins : Move other proteins, organelles and cells Proteins mediate diverse functions: Bind to one another, to other macromolecules and to small molecules such as ions Binding induces conformational change in proteins and influences its activity All the signals for protein function are contained in the protein sequences: • Where protein should go • How should be folded • How it should be modified • How long it should live • What is its function Page | 1 Protein Structure/Function Overview Molecular structure: Pr imary st ructure : Sequence Secondary : Local folding Tert iary : Long-range folding Quaternary : Mult imeric Organizat ion Super molecular : Large scale assemblies Function: • Regulat ion • Signalling • St ructure • Transport • Movement • Catalysis The function of a protein depends of the amino acid sequence: Amino acid sequence 3D structure Function I t's the structure of the protein that produces its function Page | 2 Pr imary St ructure of Proteins Amino Acid Structure: • Alpha-carbon • C-terminal and N-terminal • Hydrogen • R group Primary Structure Page | 3 P rimary Structure : Linear arrangement of the amino acid residues that compose the protein Peptide bonds : Covalent bonds that link amino acids in linear, unbranched chains Hydration Reaction : Reaction that results in the loss of water to produce peptide bonds Di rectionality: • They all add up in the same orientation...
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This note was uploaded on 06/05/2011 for the course BIO 200 taught by Professor Thomasebureau during the Fall '07 term at McGill.

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Lecture 24 - Lecture 24 Protein Structure Eventually...

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