TOPIC 9 Myology presentation 2009

TOPIC 9 Myology presentation 2009 - The Muscular System...

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Lecture outline General functions of muscles Types and Characteristics of skeletal, smooth and cardiac muscle tissue Gross and microscopic anatomy of skeletal muscle Physiology of muscle contraction Principles of whole muscle contraction Skeletal muscle metabolism
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Myology – the study of muscles Muscular tissue: skeletal, cardiac, smooth Let’s go back to our table! Functions Movement of body parts and organ contents Control of openings and passageways Maintain posture and stabilize joints Body heat production
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Connective Tissues of a Muscle 2. Perimysium 3. Epimysium 1. Endomysium Tendon 4. Deep fascia A muscle is an organ 5. Superficial fascia
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Universal Characteristics of Muscle Tissue Responsiveness/excitability Conductivity Contractility Extensibility Elasticity
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Myofibers-30 cm
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Skeletal Muscle Fiber Structure Sarcolemma transverse (T) tubules - tunnel-like infoldings that penetrate the cell, carry electric current to cell interior Sarcoplasm Myofibrils: bundles of parallel myofilaments Glycogen and myoglobin Sarcoplasmic reticulum - smooth endoplasmic reticulum series of interconnected, dilated, calcium storage sacs called terminal cisternae (pairs) Triads One T-tubule and two terminal cisternae
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Thick Filaments Made of 200 to 500 myosin molecules shaped as two entwined polypeptides (golf clubs) A bundle with heads (for cross bridges) directed outward, spirally around bundled tails actin and ATP binding site, ATPaze Myosin – contractile
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Thin Filaments Fibrous (F) actin Has two intertwined strands each subunit in the strand is globular (G) actin with an active site Tropomyosin in relaxed muscle block the active sites of 6 –7 G actins Troponin attached to each tropomyosin, binds Ca ions regulatory regulatory contractile
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Striations = Organization of Filaments Each myofibril is made up of repeating individual units= sarcomere A sarcomere is an ordered arrangement of thick & thin filaments I band H zone A band
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Relaxed vs. Contracted Sarcomere When sarcomeres contract Z discs are pulled closer together they _____ shorten all sarcomeres in a fiber will contract together and contract the fiber itself Filaments _____ change length during shortening
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Neuromuscular junction Each muscle is served by one nerve (a bundle of axons ) carrying signals to the muscle. The site of interaction between a neuron and any other cell is known as a __________ The synapse between a motor neuron and a muscle is known as the ________________ Each axon branches into multiple extensions = ___________ Each telodendrium ends in a swelling = ____________ The synaptic knob has vesicles with ____________
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TOPIC 9 Myology presentation 2009 - The Muscular System...

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