glycolysis - BCH4024- SECTION II. CARBOHYDRATE METABOLISM...

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BCH4024-- SECTION II. CARBOHYDRATE METABOLISM CARBOHYDRATE METABOLISM Robert J Cohen Robert J Cohen , Ph.D. ARB-- R3-206B - 392-4050 Email : [email protected] Office Hours: MTWF 3-4pm Web page: www.med.ufl.edu/biochem/rcohen/rcohen.html
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Readings in Mathews/Van Holde/Ahern, Readings in Mathews/Van Holde/Ahern, 3rd edition 3rd edition-- pages Overview: 414-439 Glycolysis: 446-469 Gluconeogenesis: 560-572 Glycogen Synthesis: 572-578 Glycogenolysis: 470-478 TCA Cycle: 483-509 Pentose Shunt: 511-520 ETS/Ox Phos: 522-557 Integration: 830-841 ===========================================
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Intermediary Metabolism Intermediary Metabolism ± All the reactions concerned with generating and storing energy for the needs of the cell and organism. ± All the reactions concerned with the synthesis of compounds (metabolites) used by the cell or organism.
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Introduction to Metabolism Introduction to Metabolism -- Complex substances are broken down for energy, metabolites, structural components, etc. -- Cells must synthesize new complex substances. -- Thousands of such reactions are occuring simultaneously in a single cell.
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******************************************************** - - These rxns occur with a minimum of side products, energy loss or undesired interferences and at reasonable temperatures, pH and pressure. -- All of these rxns must be controlledor regulated for optimum efficiency. *********************************************************
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************************************************************ Definitions: Definitions: Catabolism= the breakdownof complex substances. Anabolism= the synthesisof complex substances from simpler one. ***********************************************************
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Free Energy Changes In Metabolism Free Energy Changes In Metabolism -- a reminder overall G is negative (-) for catabolic processes example: higher energy A ¼ B ' C ¼ D ¼ E lower compound G 1 energy compound G 2 G = G 2 -G 1 is negative
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for an anabolic process, the G is positive (+) example: W ' V ¼ U ¼ S ¼ P -- Must supply energy, usually from ATP, to drive W ¼ Pto make the overall G is negative -- So generally catabolic processes generate energy for anabolic processes ***********************************************************
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General Pathways of Metabolism General Pathways of Metabolism -- Catabolism -- 1- Breakdown of macromolecules to building blocks -- generally hydrolytic protein polysaccharide lipid nucleic acids amino glucose, glycerol ribose,het acids other sugars fatty acids bases, phosphate - - no energy obtained- building blocks obtained here
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2- Breakdown of monomers to common intermediates amino glucose, glycerol, acids other sugars fatty acids pyruvate NH 4 + acetyl CoA citric acid cycle Ä ETS/Ox Phos Ä ATP CO 2 Oxidative processes-- produce ATP & NADH for energy
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3- Breakdown of intermediates to CO 2 and electrons is accomplished through a central oxidative pathway: -the citric acid cycle (TCA). - This cycle leads to the production of ATP by oxidative phosphorylation. ***********************************************************
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proteins polysaccharides lipids amino glucose, glycerol acids other sugars fatty acids NH 4 + pyruvate acetyl CoA Intermediates citric acid cycle CO 2 -- Anabolism Anabolism--
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Anabolism, cont’d 1- utilization of critical intermediates and components of TCA cycle to make building blocks 2- making building block requires energy = ATP 3- synthesis of macromolecules requires energy = ATP 4- note CO 2 not generally reused **********************************************************
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******************************************************** -- Some cells have specific nutrient
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This note was uploaded on 06/07/2011 for the course BCH 4024 taught by Professor Allison during the Fall '08 term at University of Florida.

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glycolysis - BCH4024- SECTION II. CARBOHYDRATE METABOLISM...

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