lecture5 - Copyright 2002 University of Florida. All Rights...

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Unformatted text preview: Copyright 2002 University of Florida. All Rights Reserved Course Subsection Outline 1. Amino Acids 2. Peptides and Peptide Bonds 3. Three-dimensional Structure of Proteins 4. Protein Dynamics and Protein Folding 5. Protein Function, Myoglobin and Hemoglobin 6. Protein Function, Contractile and Motile Systems Copyright 2002 University of Florida. All Rights Reserved Protein Function Oxygen transport proteins; Myoglobin and Hemoglobin Figure 7.1, p. 212; Biochemistry; Mathews, Van Holde, Ahern Myoglobin Hemoglobin, 4 Myoglogin-like subunits Copyright 2002 University of Florida. All Rights Reserved Iron chelated by a tetrapyrole ring system Protoporphyrin IX Heme (Ferroprotoporphyrin, lose 2 H + and add Fe 2+ ) Copyright 2002 University of Florida. All Rights Reserved Myoglobin (Mb) Oxygen Storage Protein Space-filling Model Heme in Red 8 - helices A B C D E F G H Single polypeptide chain folded into a tertiary structure contain one heme group Copyright 2002 University of Florida. All Rights Reserved Geometry of Iron Coordination in Oxymyoglobin (Myoglobin and Hemoglobin) Figure 7-2 & 7-3, p. 205-6: Lehninger Principles of Biochemistry Copyright 2002 University of Florida. All Rights Reserved Myoglobin (Mb) Oxygen Storage Protein Dynamic Images on text web site http://www.worthpublishers.com/lehninger3d/ (Start tutorial on Oxygen Binding proteins) Netscape Hypertext Document Copyright 2002 University of Florida. All Rights Reserved Geometry of Iron Coordination in Oxymyoglobin (Myoglobin and Hemoglobin) Figure 7-5 & 7-6, p. 209-10: Lehninger Principles of Biochemistry Copyright 2002 University of Florida. All Rights Reserved Mb Oxygen Binding [ ] [ ] [ ]...
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lecture5 - Copyright 2002 University of Florida. All Rights...

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