Lipid_VI_Control - activated by dephosphorylation (insulin)...

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Shuttle of Acetyl Groups to the Cytosol p779 Lehninger
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Glucose 6-Phosphate Dehydrogenase and 6-Phosphogluconate dehydrogenase Produce NADPH p778 Lehninger
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Regulation of Lipid Metabolism Metabolic regulation is achieved by Hormonally stimulated phosphorylation- dephosphorylation of regulated enzymes Metabolic regulation by allosteric control Integrative aspects of regulation
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Key Regulatory Enzyme Acetyl CoA Carboxylase Biotin Acetyl-CoA + ATP + HCO 3 - Malonyl-CoA + ADP + P i + H + inactivated by phosphorylation (glucagon)
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Unformatted text preview: activated by dephosphorylation (insulin) allosterically activated by citrate I. Hormonal Control with Glucagon Binding of the glucagon to the plasma membrane results in the subsequent phosphorylation of enzymes by protein kinases. a. Acetyl CoA carboxylase ( inhibited) b. Hormone sensitive lipase ( activated) c. Pyruvate dehydrogenase ( inhibited) With the following results a. Decreased fatty acid synthesis b. Increased gluconeogenesis c. Increased mobilization of stored fats...
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Lipid_VI_Control - activated by dephosphorylation (insulin)...

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