lecture11_2006_jrl

lecture11_2006_jrl - Today's Lecture 11 Wed Oct 25 Driving...

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Today’s Lecture 11) Wed, Oct 25: Driving interactions between spins a. Heteronuclear interactions in solution b. Heteronuclear interactions in solids c. Improving sensitivity d. Improving resolution
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What do we mean by heteronuclear interactions? Interactions between two atoms with different nuclear properties 1 H 15 N 1 H 13 C 15 N 13 C 13 C 14 N 1 H 2 H spin ½ interactions spin ½ interacting with spin 1 These interactions follow the same spin physics as homonuclear interactions. HOWEVER there is one important difference…. .
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Each nucleus can be treated differently by RF pulses We can detect nuclei without directly observing them Each nucleus has a different γ This leads to: Different polarizations Different frequencies Also, their different electronic properties lead to different chemical shift ranges How can we exploit this?
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Why Heteronuclear NMR? Overlapping 1 H resonances can be resolved using frequencies of attached heteronuclei Heteronuclei create efficient pathways to correlate atoms along the backbone and side-
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This note was uploaded on 06/07/2011 for the course BCH 6745 taught by Professor Staff during the Spring '08 term at University of Florida.

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lecture11_2006_jrl - Today's Lecture 11 Wed Oct 25 Driving...

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