Boyko...Ostrander.PLoSBiol.2010 - A Simple Genetic...

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A Simple Genetic Architecture Underlies Morphological Variation in Dogs Adam R. Boyko 1,2 . , Pascale Quignon 3 . , Lin Li 2 . , Jeffrey J. Schoenebeck 3 , Jeremiah D. Degenhardt 2 , Kirk E. Lohmueller 2 , Keyan Zhao 1,2 , Abra Brisbin 2 , Heidi G. Parker 3 , Bridgett M. vonHoldt 4 , Michele Cargill 5 , Adam Auton 2 , Andy Reynolds 2 , Abdel G. Elkahloun 3 , Marta Castelhano 6 , Dana S. Mosher 3 , Nathan B. Sutter 2,6 , Gary S. Johnson 7 , John Novembre 4 , Melissa J. Hubisz 2 , Adam Siepel 2 , Robert K. Wayne 4 , Carlos D. Bustamante 1,2 " * , Elaine A. Ostrander 3 " * 1 Department of Genetics, Stanford School of Medicine, Stanford, California, United States of America, 2 Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America, 3 Cancer Genetic Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America, 4 Department of Ecology and Environmental Biology, University of California, Los Angeles, California, United States of America, 5 Affymetrix Corporation, Santa Clara, California, United States of America, 6 Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America, 7 Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, United States of America Abstract Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal. Here, we generate a high density map of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10 outbred African shelter dogs across 60,968 single-nucleotide polymorphisms (SNPs). Coupling this genomic resource with external measurements from breed standards and individuals as well as skeletal measurements from museum specimens, we identify 51 regions of the dog genome associated with phenotypic variation among breeds in 57 traits. The complex traits include average breed body size and external body dimensions and cranial, dental, and long bone shape and size with and without allometric scaling. In contrast to the results from association mapping of quantitative traits in humans and domesticated plants, we find that across dog breeds, a small number of quantitative trait loci ( # 3) explain the majority of phenotypic variation for most of the traits we studied. In addition, many genomic regions show signatures of recent selection, with most of the highly differentiated regions being associated with breed-defining traits such as body size, coat characteristics, and ear floppiness. Our results demonstrate the efficacy of mapping multiple traits in the domestic dog using a database of genotyped individuals and highlight the important role human-directed selection has played in altering the genetic architecture of key traits in this important species. Citation:
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This note was uploaded on 06/08/2011 for the course PCB 4674 taught by Professor Baer during the Fall '08 term at University of Florida.

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Boyko...Ostrander.PLoSBiol.2010 - A Simple Genetic...

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