gene conversion - GENE CONVERSION 3/3/11 In class, we...

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GENE CONVERSION 3/3/11 In class, we diagrammed and discussed the single strand break model of homologous recombination. We also pointed out that the resultant DNA duplexes, after crossover, would each consist of heteroduplex DNA. Heteroduplex DNA refers to a hybrid DNA duplex, where one strand is derived from one of the two starting parent duplexes (with the other strand then being derived from the other starting parent duplex). I.e., see our handout on homologous recombination where the final DNA duplexes consist of “squiggly DNA” pairing with “straight DNA.” As also stressed in class, like all current models of homologous recombination, the single strand break model depends on sequence similarity (homology) between the two starting parent duplexes (“wherever sequence similarity exists crossover can occur”). However, please recognize that “sequence similarity” is not the same as “identity.” The former indicates being alike, the latter indicates being identical. In homologous crossover, we are dealing with homologous DNAs (i.e.,
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gene conversion - GENE CONVERSION 3/3/11 In class, we...

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