Haldane - MAPPING FUNCTION As learned in class as the map...

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1 MAPPING FUNCTION 1/20/11 As learned in class, as the map distance between two linked genes increases, the probability of multiple crossovers between them increases too. Thus, the observed frequency of crossover recombination between the two genes will underestimate the true map distance between them if the two genes are quite far apart. To correct for these underestimates/errors, the great geneticist, J.B.S. Haldane developed a mapping function (i.e., an equation to correct for these underestimates due to multiple crossovers). His mapping function relies on the Poisson equation, so you should refer back to the Poisson web handout (available at our course web site). Once again, the Poisson equation is: e m m x x x P ! ) ( , where m is the mean number of events for a defined unit of time multiplied by the frequency of the event (e.g., crossovers per meiosis); x is the number of successes (e.g., specific number of actual crossovers), and e is the natural base (2.717271727….
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This note was uploaded on 06/08/2011 for the course PCB 3063 taught by Professor Marta during the Spring '08 term at University of Florida.

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Haldane - MAPPING FUNCTION As learned in class as the map...

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