handout 2.17.11 - 2/17/11 1. Telomere: The specialized ends...

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1 2/17/11 1. Telomere: The specialized ends of linear chromosomes, which consist of repetitive DNA. Telomeres serve to cap/protect the ends of linear chromosomes and to allow for the replication of these ends (i.e., the “telomere problem”). 2. Telomerase: Eukaryotic reverse transcriptase for the synthesis of telomeres. Telomerase is a ribonucleoprotein (RNA/protein complex) that carries its own RNA template for DNA synthesis 3. Replisome: The large molecular “machine” (i.e., aggregation of different enzymes) at the replication fork, which work together to ensure the accurate and efficient replication of both DNA strands 4. Promoter: Special DNA sequence, just upstream (5’) to gene, to which RNA polymerase recognizes and binds for the initiation of transcription 5. Exon: Gene regions that are retained in mRNA, therefore transcribed and MAY be translated into protein Intron: Gene regions that are transcribed but cleaved out of mRNA, therefore cannot be translated 6. Spliceosome: Ribonucleoprotein (RNA/protein complex) that removes introns by 2-step lariat method (Figure 14-14) 7. Ribozyme: Catalytic RNA that combines the genetic information of a nucleic acid with the catalytic capability of an enzyme 8. Genome: Total haploid DNA complement of a cell, individual, or species Proteome: Total set of proteins that can be produced by a cell, individual, or species --------------------------------------------------------------------------------------------------------------------------------------- T2 PHAGES (Note that “r” and “h” are without minus signs) Plaque size Plaque appearance r + – small h + – cloudy r – large h – clear Mixed infection progeny #progeny plaques r + h 42 r h + 34 r + h + 12 r h 12 Total 100 Also, the crossover experiments (i.e., “24 cM distance”) was done with T2 phages
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This note was uploaded on 06/08/2011 for the course PCB 3063 taught by Professor Marta during the Spring '08 term at University of Florida.

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handout 2.17.11 - 2/17/11 1. Telomere: The specialized ends...

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