Bioprocess- fifth and sixth 1h+1h

Bioprocess fifth - Material Balance for Batch Continuous and Fed-Batch Biological Processes Learning outcomes of the lecture Derive and apply the

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Material Balance for Batch, Continuous and Fed-Batch Biological Processes
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Learning outcomes of the lecture…. - Derive and apply the relevant material balances to a Batch, Fed-Batch and CSTR bioreactor .
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General Balance Equations
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All our reactor analyses are based on using the General Balance Equations accumulation = input - output + reaction
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Cell Mass Balance: Rate of accumulation of cells, g/s Rate of cells entering, g/s = Rate of cells leaving, g/s + Rate of generation of live cells, g/s d(VC C ) = Q in C C in - Q out C Cout + V r G dt V= Culture Volume Q in = Volumetric flow entering the reactor C Cin = Cell concentration entering the reactor Q out = Volumetric flow leaving the reactor C Cout = Cell concentration leaving the reactor
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Batch, Fed-Batch and Continuous Processes Batch – Closed system (except for aeration) containing a limited amount of medium. All the nutrients are added at the beginning of the fermentation. Fed-Batch – is essentially a batch culture which is supplied with either fresh nutrients , for example, substrates, or additives such as precursors to products . Continuous Open system in which medium is continuously added to the bioreactor and an equal volume of fermented medium is simultaneously removed. Several factors remain constant with time:
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This note was uploaded on 06/06/2011 for the course CHEM 3040 taught by Professor Reddy during the Spring '10 term at Taylor's.

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Bioprocess fifth - Material Balance for Batch Continuous and Fed-Batch Biological Processes Learning outcomes of the lecture Derive and apply the

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