Bioprocess- third 2h lecture

Bioprocess- third 2h lecture - Enzyme-Catalyzed Reactions...

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Enzyme-Catalyzed Reactions
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Learning outcomes of the lecture…. - Demonstrate an understanding of the kinetics of enzyme- catalyzed reactions. - Explain the “lock and key” and “induced fit” model of enzymatic action. - Demonstrate an understanding of the mechanism of enzyme action. - Understand the Michaelis-Menten equation and ability to apply the Michaelis-Menten equation to the analysis of enzyme kinetics. - Explain the different phases of cell growth.
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Enzymes They are produced only by living organisms and commercial enzymes are generally produced by bacteria. Most of enzymes are high-molecular weight proteins or protein-like substances that acts on a substrate (reactant molecule) to transform it chemically at a greatly accelerated rate, usually 10 3 to 10 17 times faster than the uncatalyzed rate. Enzymes are specific: one enzyme can usually catalyze only one type of reaction.
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Enzymes They are present in small quantities in the reaction and are not consumed during the course of the reaction nor do they affect the chemical reaction equilibrium. Uncatalyzed reaction : S → P Catalyzed reaction : S + E E•S → E + P Catalytic activity is revealed by studying enzyme kinetics!
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Activation Energy They provide an alternate pathway for the reaction to occur thereby requiring lower activation energy.
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