pharm 1000 Test 3 material

pharm 1000 Test 3 material - 13:02:00 Chemotherapy...

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Unformatted text preview: 02/11/2010 13:02:00 Chemotherapy Definitions • parasites – foreigh organism • host – you, the patient, or whatever has the parasite • originally names for things that kill a parasity • therapy must be more toxic to parasite than to the patient • trick of chemotherapy is finding the differnce between you and the parasite • antibiotis – microbes and • antiseptics – destroy microbes on skin or mucous membranes – can’t take internally bacterial vs. animal cells prokaryotic- bacterial eukaryotic cells – animals • both need same basic needs • metabolic reactions are similar too ← ← Evolution Of chemotherapeutic agents ← Ehrlich – father of it • Staining tissues • Immunology • 1910 – syphilis – first chemotherapeutic agent o before that – ppl used mercury ← Domagk • Prontosil – sulfa drug • Single drug that you can use for a wide range of bacteria o Eventually developed diuretic agents o Oral antidiabetic ← Alexander Fkeming • Penicillin – 1929 – first antibiotic o English generation died out ← ← Rene Dubos – streptomyocin – killed of TB • Antibiotics in soil Chemotherapeutic agents: Mechanism of Action Bacteriostatic vs Bacteriocidal ←- bacteriacidal - number of bacteria die off when penicillin is given ←- bacteriostatic drugs – kills replication • helps because it helps immune system – ← inhibition of cell wall synthesis – • penicillin – cell wall protects it ← inhibition of cell membrane function – humans have one • cell membrane – regulates what goes in and comes out Drug Resistance Innate vs Genetic Resistance • can’t use antibiotics against viruses ← There are a number of ways that bacteria resist antibiotics ← Reduction of intracellular drug concentration • Referring to concentration Inside the cell ← Inactivation of antimicrobial drug • PCN – split molecule ← Alteration or elimination of Drug target • Eliminating cell wall ← ← Drug Resistance: Potential Consequences • MRSA – mefasilin o Treatment failure o Increased morbidity – presence of disease mortality – dying hospitalization healthcare costs doses increases toxicity/cost use more toxic and expensive drugs ← ← The right antibiotic saves lives – ← ← Uses and Misuses of antibiotics ← Human Diseases • Causes of death in USA o 1900 – top 3 – pneumonia, TB, Diarrhea-enteritis • 2000 - #6 – pneumonia influenza (3%) o the reason why is because we have the drugs now rational use of Antibiotics • diagnosis • bacterial sensitivity to drug o drug sharing • adequate dose/adequate time (prevent bacterial resistance)...
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pharm 1000 Test 3 material - 13:02:00 Chemotherapy...

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