pharm 1000 Test 3 material

pharm 1000 Test 3 material - 02/11/2010 13:02:00...

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Unformatted text preview: 02/11/2010 13:02:00 Chemotherapy Definitions parasites foreigh organism host you, the patient, or whatever has the parasite originally names for things that kill a parasity therapy must be more toxic to parasite than to the patient trick of chemotherapy is finding the differnce between you and the parasite antibiotis microbes and antiseptics destroy microbes on skin or mucous membranes cant take internally bacterial vs. animal cells prokaryotic- bacterial eukaryotic cells animals both need same basic needs metabolic reactions are similar too Evolution Of chemotherapeutic agents Ehrlich father of it Staining tissues Immunology 1910 syphilis first chemotherapeutic agent o before that ppl used mercury Domagk Prontosil sulfa drug Single drug that you can use for a wide range of bacteria o Eventually developed diuretic agents o Oral antidiabetic Alexander Fkeming Penicillin 1929 first antibiotic o English generation died out Rene Dubos streptomyocin killed of TB Antibiotics in soil Chemotherapeutic agents: Mechanism of Action Bacteriostatic vs Bacteriocidal - bacteriacidal - number of bacteria die off when penicillin is given - bacteriostatic drugs kills replication helps because it helps immune system inhibition of cell wall synthesis penicillin cell wall protects it inhibition of cell membrane function humans have one cell membrane regulates what goes in and comes out Drug Resistance Innate vs Genetic Resistance cant use antibiotics against viruses There are a number of ways that bacteria resist antibiotics Reduction of intracellular drug concentration Referring to concentration Inside the cell Inactivation of antimicrobial drug PCN split molecule Alteration or elimination of Drug target Eliminating cell wall Drug Resistance: Potential Consequences MRSA mefasilin o Treatment failure o Increased morbidity presence of disease mortality dying hospitalization healthcare costs doses increases toxicity/cost use more toxic and expensive drugs The right antibiotic saves lives Uses and Misuses of antibiotics Human Diseases Causes of death in USA o 1900 top 3 pneumonia, TB, Diarrhea-enteritis 2000 - #6 pneumonia influenza (3%) o the reason why is because we have the drugs now rational use of Antibiotics diagnosis bacterial sensitivity to drug o drug sharing adequate dose/adequate time (prevent bacterial resistance)...
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pharm 1000 Test 3 material - 02/11/2010 13:02:00...

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