10 pharm 1000

10 pharm 1000 - 9/16/10 Pharm 1001 Drug History - Tolerance...

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9/16/10 Pharm 1001 Drug History - Tolerance – the more you take it the less effect it has - Cumulative effects – adding effects of it because it isn’t being eliminated from the body - Drug-drug interactions o Additive effects – alcohol with sleeping pills - Antagonistic effects o Pharmacokinetic/dispositional antagonism Enzyme induction – speed it it sometimes. Ex using a blood thinner…if something too high then bleed easily. Too low = won’t coagulate Cigarette smoking o Pharmacological/receptor antagonism Opioid antagoinist naloxone (Narcan) vs. heroin o Physiological/functional antagonism o Chemical antagonism or inactivation - Combination Drug Therapy: Potential benefits o Different mechanisms beneficial effect Lower dose each (side effects, cost) Prevent/reduce undesirable side effects 5. The Development of New Drugs What is a perfect drug? - Affordable, non addictive, easily administered How many drug products are there? -
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This note was uploaded on 06/05/2011 for the course COMM 1100 taught by Professor Na during the Spring '10 term at UConn.

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10 pharm 1000 - 9/16/10 Pharm 1001 Drug History - Tolerance...

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