PPOK - 11/24/2008 PENYAKIT PARU OBSTRUKTIF KRONIK (PPOK)...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
11/24/2008 1 PENYAKIT PARU OBSTRUKTIF KRONIK (PPOK) Dr. Farida A. Soetedjo, Sp.P Bag. Ilmu Penyakit Dalam FK - UWKS 2007 DEFINISI Penyakit paru yg ditandai oleh hambatan aliran udara yg bersifat non reversibel atau reversibel sebagian. Hambatan aliran udara bersifat progresif & berhubungan dg respons inflamasi abnormal paru thd partikel atau gas beracun.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
11/24/2008 2 FAKTOR RISIKO Host: - Genetik: Defisiensi 1 anti tripsin - Hipereaktivitas bronkus Lingkungan: - Asap rokok (faktor risiko utama - sigaret) - Partikel debu & bahan kimia perindustrian - Polusi udara - Infeksi - Status sosial PATOGENESA Keradangan kronis pd sal. napas, parenkim paru, sistem vaskuler paru pe makrofag, limfosit T (CD8+), netrofil release mediator LB4, IL8, TNF Imbalance proteinase – anti proteinase Stres oksidatif Ketiga faktor diatas akan merusak struktur paru.
Background image of page 2
3 PATOLOGI Saluran napas besar Hipertrofi kelenjar & pe jumlah sel Goblet hiper- sekresi mukus Saluran napas kecil Recycled injury & repair dinding sal. napas remo- deling (pe kolagen & jar. ikat) penyempitan Parenkim paru Destruksi parenkim emfisema sentrilobuler Vaskuler pulmonal Penebalan dd pembuluh darah KLINIS Keluhan utama: sesak napas, batuk, dahak Sesak timbul progresif sp mengganggu aktivitas, men-dadak memberat bila tjd eksaserbasi Batuk kronis, memberat pagi hari, dahak mukoid purulen bila eksaserbasi Suara mengi (wheezing) Batuk darah blood-streaked purulen sputum
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 06/07/2011 for the course EE 80119 taught by Professor Bakta during the Spring '11 term at University of Zagreb Faculty of Electrical Engineering and Computing.

Page1 / 12

PPOK - 11/24/2008 PENYAKIT PARU OBSTRUKTIF KRONIK (PPOK)...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online