05 - Synaptic Transmission

05 - Synaptic Transmission - Synaptic Transmission

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Synaptic Transmission http://outreach.mcb.harvard.edu/animations/synaptic.swf
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Lecture Overview The synapse and neurotransmitter function Variety of Neurotransmitters Neurotransmitter systems and behavior
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Discovery of the 1 st Neurotransmitter by Otto Loewi (1921) Used 2 frog hearts. Heart #1 was still connected to the vagus nerve and placed in saline. Heart #2 was in a 2nd chamber that was connected to chamber 1. Thus, saline from chamber #1 was allowed to flow into chamber #2. E- stim of the vagus nerve (attached to heart #1) caused it to slow down. After a delay, heart #2 slowed down. E- stim of the vagus nerve released a chemical into the fluid of chamber #1 that flowed into chamber #2. He called this chemical "Vagusstoff". NT called acetylcholine
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Loewi’s Experiment
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Synaptic Transmission Pre synaptic Neuron Post synaptic Neuron
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Synapse Point where 1 neuron communicates w/ another Presynaptic membrane is typically an axon Synaptic Cleft: the empty space in a synapse Postsynaptic membrane can be: A dendrite (axodendritic synapse) A cell body (axosomatic synapse) Another axon (axoaxonic synapse)
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Synapse types
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Synapse: Important Microstructures Synaptic vesicles: organelle filled with chemicals Active zones: site for chem release in the presynaptic membrane. Postsynaptic membrane: site for receptors. Convert incoming chem signal to either intracellular electrical or chem signals.
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VESICLES ACTIVE ZONE POST SYNAPTIC MEMBRANE
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Chemical Events at the Synapse Transmission of a message across the synapse occurs by chemical means. Neurotransmitters (NT): chemicals that travel across the synapse and allow communication between neurons.
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Sending the message AP arrives at terminal Cell makes NT Stores NT in vesicles Or enzymes make and store NT AP causes NT to release into synaptic cleft
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This note was uploaded on 06/09/2011 for the course PSYCH 180 taught by Professor Ziegler during the Spring '10 term at CUNY Hunter.

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05 - Synaptic Transmission - Synaptic Transmission

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