summary-lecture10 - WINTER 2011 GENETICS 2CO3 LECTURE 10:...

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WINTER 2011 GENETICS 2CO3 LECTURE 10: MOLECULAR MARKERS USED IN GENETIC MAPPING OVERVIEW In preparation for the upcoming lectures, we look at molecular markers in the genome – genetic variation that is not associated with genes. OBJECTIVES At the end of this lecture, you will be able to: calculate recombination frequencies used in human mapping describe the classes of molecular markers, in particular SNPs and STRs state which molecular technique is most appropriate for visualizing a molecular marker interpret the results of these molecular techniques REFERENCES IN TEXT (PIERCE; GENETICS: A CONCEPTUAL APPROACH): Molecular markers: Chapter 7: Mapping with Molecular Markers p.185 Chapter 19: RFLPs and linkage, p.254 Chapter 20: Maps, p.548-549; Molecular markers – SNPs Useful references for detection of molecular markers: p.508-509 (Southern blots), p.513-515 (PCR) CONCEPTS MAPPING HUMAN GENES Linkage analysis in humans is not as simple as in model organisms. Traditional linkage mapping can
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summary-lecture10 - WINTER 2011 GENETICS 2CO3 LECTURE 10:...

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