PRACTICE EXAM - McMaster University (Biology 2C03 Final...

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McMaster University (Biology 2C03 Final Examination) Page 1 of 18 BIOLOGY 2C03 Practice Exam Questions. Section A - Multiple Choice 1. How many unique human genomes have been sequenced and published to date? a) 1 b) 2 c) 3 d) 5 e) 10 2. Given the following map: Are genes a and c linked? a) No, unlinked, mapping data is in error b) Yes, linked, they are part of a single linkage map c) No, unlinked, but on the same chromosome d) Yes, linked, but on different chromosomes e) No, unlinked, since the will assort independently 3. In a sequenced genome, candidate protein-coding genes are identified by searching for: a) STRs b) RFLPs c) ESTs d) SNPs e) ORFs 4. What is the mechanism that holds together homologous chromosomes from prophase I through to anaphase I? a) synaptonemal complex b) proteins (cohesins) that lie between replicated sister chromatids are sufficient c) chiasmata are sufficient d) both proteins (cohesins) between sister chromatids and chiasmata are required e) homologous association proteins (HAPs) …continued on next page a b c 40 mu 30 mu
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McMaster University (Biology 2C03 Final Examination) Page 2 of 18 5. A DNA microarray is hybridized with two populations of labeled cDNA. mRNA is extracted from kidney tissue and reverse transcribed into cDNAs that are lablelled with a red fluorescent tag mRNA is extracted from liver tissue and reverse transcribed into cDNAs that are labelled with a green fluorescent tag What can you conclude if you see a spot on the microarray that fluoresces yellow? a) the gene is present in the genome of the kidney and the liver cells b) the gene is present in twice as many copies in the genome of the liver cells c) the gene is transcribed in neither cell type d) the gene is transcribed a higher levels in the liver cells e) the gene is transcribed at equal levels in both the kidney and the liver cells 6. A mutant allele of corn leads to absence of purple pigment in the kernel and the kernel appear yellow. The allele, however, is unstable, reverting quite late, yet often, in development. The expected phenotype of kernels homozygous for this mutation is: a) fully purple b) fully yellow c) yellow with few large purple spots d) yellow with few small purple spots e) yellow with many small purple spots 7. Site-directed mutagenesis is used to change a codon from AAA lysine to AGA arginine, but the phenotype produced is still wild type. This type of mutation is called: a) suppression b) silent c) nonsense d) missense e) frameshift 8. A mutation results in an abnormally short protein. The mutation was most likely of a type called: a) missense b) nonsense c) antisense d) silent e) suppressor 9. During mutagenic treatment with nitrous acid, an adenine deaminates to form hypoxanthine, which bonds like guanine. The mutational event would be (basepairs are indicated): a) A-T to C-G b) A-T to G-C c) A-T to TA d) G-C to A-T e) G-C to T-A …continued on next page
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McMaster University (Biology 2C03 Final Examination)
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PRACTICE EXAM - McMaster University (Biology 2C03 Final...

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