{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

HMM - Hidden Markov Models Chapter 11 CG islands The...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Hidden Markov Models Chapter 11
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
CG “islands” The dinucleotide “CG” is rare C in a “CG” often gets “methylated” and the resulting C then mutates to T Methylation is suppressed in some areas of genome, called “CG islands” Such CG islands often found around genes Problem: find CG islands in whole genome
Background image of page 2
CG island normal high CG rare CG Two states. Each state emits sequence. • Sequence emitted by “CG island” state is high in CG frequency Concatenation of sequence emissions = genome
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon