CG “islands”•The dinucleotide “CG” is rare–C in a “CG” often gets “methylated” and the resulting C then mutates to T•Methylation is suppressed in some areas of genome, called “CG islands”•Such CG islands often found around genes•Problem: find CG islands in whole genome
CG islandnormalhigh CGrare CG•Two states. •Each state emits sequence.• Sequence emitted by “CG island” state is high in CG frequency•Concatenation of sequence emissions = genome
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