Mol.Bio.PartII - Molecular Biology Part II Discovery of DNA...

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Molecular Biology Part II
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Discovery of DNA DNA Sequences Chargaff and Vischer, 1949 DNA consisting of A, T, G, C Adenine, Guanine, Cytosine, Thymine Chargaff Rule Noticing #A #T and #G #C A strange but possibly meaningless phenomenon. Wow!! A Double Helix Watson and Crick, Nature, April 25, 1953 Rich, 1973 Structural biologist at MIT. DNA s structure in atomic resolution. Crick Watson
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Watson & Crick “…the secret of life” Watson: a zoologist, Crick: a physicist In 1947 Crick knew no biology and practically no organic chemistry or crystallography. .” – www.nobel.se Applying Chagraff’s rules and the X -ray image from Rosalind Franklin, they constructed a “tinkertoy” model showing the double helix Their 1953 Nature paper: “It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.” Rosalind Franklin with X-ray image of DNA
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The Story of Double helix The discovery of double helix by James Watson and Francis Crick in 1953 was preceded by several other important discoveries in Biology: 1) Erwin Chargaff (Columbia University) found experimentally that in DNA the number of adenine residues equals the
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This note was uploaded on 06/12/2011 for the course CAP 5510 taught by Professor Staff during the Spring '08 term at University of Central Florida.

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Mol.Bio.PartII - Molecular Biology Part II Discovery of DNA...

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