File-012 - BIO119 File-012 McCague Lecture Notes:...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
BIO119 McCague File-012 Lecture Notes: Non-Specific Defense Mechanisms: Age of Chemotherapy began with these discoveries: - Salvarsan 606 (“Magic Bullet”) – 1909 – Paul Ehrlich - Sulfa Drugs – Coal tar extracts – 1935 – G. Domagk - Penicillin – From Penicillium notatum – 1929 – A. Fleming Blood - Composition and Nature of Blood - Is an important non-specific (phagocytosis) and specific (antibody) defense mechanism - Blood is a special connective tissue - The liquid fraction is plasma - The solid fraction is formed elements or blood cells - Fibers make their appearance in plasma as fibrin when blood clots - Blood constitutes 7% of the body weight; a 70 kg person has 5 liters (quarts) Erythrocytes or Rubricytes - Biconcave disks – the absorb and carry gas, mainly O 2 - Varian shapes occur pathologically, such as “sickle cells” Number o 5.2 million/cubic mm. Males o 4.7 million/cubic mm. Female - Total Number 25 million millions (That’s 4X around the earth the earth if end to end) - A marked decrease in number occurs in pernicious anemia. - Increase in number occurs at high attitude or in CO (C-monoxide) exposure. Color - A fresh corpuscle is pale greenish-yellow, together they are red. They stain pink with acid dyes (Wright’s stain) Structure - Non-nucleated when mature - Membrane is a lipo-protein complex - About 1% of RBC’s are not quite mature. These contain a RNA network and are called reticulocytes-stain blue with brilliant cresyl blue dye - They are flexible and elastic, distort momentarily when they pass a small blood vessel (capillary) 1
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
BIO119 McCague File-012 Rouleaux - columns of corpuscles, stacked like a pile of coins Hemolysis - accomplished by agents that injure plasma membranes - Example: lipid solvents, either, bile salts, snake venom, bacterial hemolysin (Strptococcus) - Agglutination (i.e. clumping) of corpuscles is induced by agents, such as acid-salt solutions; glucose solutions, agglutinins - Agglutinins in plasma, furnish the basis for the four blood types - These are responsible for specific compatibilities and incompatibilities - 95% of Dry weight of RBC’s is due to hemoglobin a protein of 557 amino acids + iron that carries O 2 - Life-span – 127 days: This means 2 1 / 2 million new cells enter circulation each
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 06/13/2011 for the course BIO 119 taught by Professor Stevendroho during the Spring '11 term at Moraine Valley Community College.

Page1 / 6

File-012 - BIO119 File-012 McCague Lecture Notes:...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online