Feb 28 talk - CHALLENGES AND OPPORTUNITIES OF STEM CELL...

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CHALLENGES AND OPPORTUNITIES OF STEM CELL RESEARCH IN THE 21 ST CENTURY HUMAN ANATOMY & PHYSIOLOGY SOCIETY MIDWEST REGIONAL CONFERENCE February 28, 2004 Mary J.C. Hendrix, Ph.D. President and Scientific Director Children’s Memorial Institute for Education and Research
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An Ethical Debate for the 21 st Century: A Question of Life or Death Untangling the knottiest of ethical dilemmas What is the value of this clump of cells? Another human or a new hope for the diseased and the dying?
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3 What is a stem cell? An undifferentiated cell that can both renew itself (divide for indefinite periods in culture) and give rise to specialized cells
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4 Contains more than 10 trillion cells, of more than 250 different types Some tissues continually renew themselves from stem cells (adult stem cells) THE HUMAN BODY Skin stem cell Neuronal stem cell Intestinal stem cell Bone marrow stem cell
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5 Embryonic Stem Cells Unlimited capacity for renewal Broader pluripotency (can become nearly every cell type in body) Easier access to stem cells Large number of available stem cells Adult Stem Cells Limited capacity for renewal Limited pluripotency Difficult access to and identification of the stem cells Limited number of available stem cells Embryonic vs. Adult Stem Cells
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6 Sources of Embryonic Stem Cells Day 5 Source: NIH website “Stem cells: A Primer” “cell line” Inner Cell Mass of embryos (blastocysts) in excess from fertility treatments (Embryonic Germ Cells from fetal tissue from elective abortions)
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7 Embryonic Stem Cells derived from Nuclear Transplantation (or Somatic Cell Nuclear Transfer-SCNT) Day 5
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8 Source: NIH website “Stem cells: A Primer”
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9
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10 Presidential decision – August 9, 2001 NIH can fund work on embryonic stem cell lines derived before August 9, 2001 Greater than 60 human embryonic stem cell lines exist (78 lines listed as eligible by NIH as of June 2002) Other criteria that must be met: Cells derived from embryos created for reproductive purposes in excess of clinical need Proper informed consent obtained No financial inducement for donation Bioethicist Leon Kass named as chair of President’s Council to monitor stem cell research and other issues related to biomedical innovation
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This note was uploaded on 06/13/2011 for the course BIO 119 taught by Professor Stevendroho during the Spring '11 term at Moraine Valley Community College.

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Feb 28 talk - CHALLENGES AND OPPORTUNITIES OF STEM CELL...

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