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Unformatted text preview: Cyclic AMP by adenylyl cyclase Calcium as second messenger IP3 and DAG as second messengers to release calcium o Protein phosphatases o 3)Response Trigger specific cellular response Membrane receptors: 1) G protein-coupled receptor a. switch on and off b. G from GTP 2) receptor tyrosine kinase a. regulate enzyme activity 3) ion channel receptor a. ligand gated channel Intracellular receptors (cytoplasm or nuclear) 1) transcription factor to turn on gene Types of Responses o Plasma membrane receptors o Enzyme activation o Contract or relax o secretion o ion movement (depolarization, hyperpolarization) o Nuclear receptor o mitosis o protein synthesis via gene activation o termination of signal o enzyme to break down chemical o reuptake o cells regulate receptors for chemicals upregulate downregulate o apoptosis...
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- Fall '06
- Cell Signaling