BIO361L1-1 - - - u/Lf . 3 w INFECTION - -> D AMAGE TO...

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- - u/L f3.w INFECTION ---> DAMAGE TO HOST----------- > INFECTIOUS (COLONIZATION) DISEASE . ETIOLOGLC(Aj-) AGENT: MICROBE RESPONSIBLE FOR THE t CSISEASE; MICROBES CAN BE &CTERIA, FUNGI, y VIRUSES, PR@&OZOA 'C . E L PATHOGEMfWJV IS THE MICROBE'S ITY TO CAUSE INFEC'~IOUS&~%EASE S MICROBE'S pATF$OGENIc < ..................... > HOST DEFENSES POTENTIAL (PATHOGENICITY) D 0 I. COLONIZATION PHYSICAL EEARRIE~S 2. MULTIPLlCATlON CHEMICAL BARRIERS - 3. PENETRATION 3. NONSPECIFIC IMMUNITY : S . (INVASION)* ' (PHAG~CYTES) 4 ~ 4. TOXIGENICITY* SPECIFIC IMWIUNITK i 1; s (ANTIBODIES, CELL MEDIATED) - INVAS~VE MICROBE ---------------; --------A- , ' TBXIGENIC NI[CROBE VlBRlO CHOLERAE ,, '#I ChOSTRIDiUjM BOTULINU-M --
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- -- 7 y STAPHYLOCOCCI AND MICROCOCCI )I BOTH IN FAMILY MICROCOCCACEAE E MICROCOCCUS- MAINLY ENVCRONMENTAL- CAN BE R ISOLATED FROM COMPROMISED INDIVIDUALS (BLOOD, ETC.); DOES NOT FERMENT GLUCOSE (MAY OXIDIZE IT); RESISTANT TO FURAZOLIDONE; GRAM MORPHOLOGY- N CLUSTERS AND 3D TETRADS i d COAGULASE NEGATIVE STAPHYLOCOCCUS- MANY SPECIES- W S. EPlDERMlDlS MOST COMMON; ALSO SEEN: & HOMINIS, - S. HAEMOLYTICUS, NEWLY DESCRIBED LUGDUNENSIS; - PROBLEM IN INDIVIDUALS WITH INDWELLING DEVICES- PROSTHETIC HEART VALVES, IV CATHETERS, HEMODIALYSIS SHUNTS, ETC.(THESE BACTERIA MAKE AN D EXTRACELLULAR SLIME OR OTHER ADHESIN AND COLONIZE 0 THESE DEVICES); BECOMING RESISTANT TO MULTIPLE ANTIBIOTICS- EMERGING PROBLEM (METHICILLIN RESISTANT NOT UNCOMMON); STAPHYLOCOCCUS SAPROPHYTICUS- t NOVOBIOCIN RESISTANT- UTI'S IN YOUNG FEMALES L ? ALl WEUS- COAGULASE POSITIVE STAPH. UMBER OF PURULENT SUPPURATIVg DISEASES FROM PIMPLES AND FULMINATIWG BSCESSES. HAVE NUMEROU~~ HEMOLYSHVS, EUCOCIDINS, HYALURONIDASE, PHOS~HOLIPASE, ETC. THAT DESTROY TISSUE; ENTEROTOXINS CAN BE PRODUCED IN CERTAIN POORLY HANDLED FOODS; TOXIC SHOCK SYNDROME IS CAUSED BY TSST-1 TOXIN MADE BY CERTAIN STRAINS (MOST ARE NOW WOUND ASSOCIATED- NOT MENSTRUAL); NUMEROUS STRAINS AWE MULTIPLY t RESISTANT ANTIMICROBIAL. AGENTS-METHiCILLlN i STAPH. AUREUS (MRSA) i r
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STREPTOCOCCI AND ENTEROCOCCI t 1. GRAM POSITIVE COCCI IN PAIRS OR CHAINS- DlVlSlOlU ALONG ONE PLANE, CATALASE NEGATIVE 2. CHARACTERIZED BY CELL WALL CARBOHYDRATE "GROUP" ANTIGENS 3. COMMOIU MEMBERS OF NORMAL FLORA OF OROINASOPHARYNX ("VIRIDANS" STREPTOC06CI); INTESTINE (ENTEROCOCCI) )1 4. MANY IMPORTANT PATHOGENS: A. GROUP A STREPTOCOCCI (BETA-HEMOLY'I'IC) FRANK PATHOGENS- PHARYNGITIS, PYODERMA,SYSTEMIC INFECTIONS B. GROUP B STREPTOCOCCI (ALPHA, BETA, OR GAMMA HEMOLY1-IC) OPPORTUNISrIC PATHOGENS- PUERPERAL SEPSIS OR SEPTlCEMlAlMENlNGlTlS OF NEONATE )I C. GROUP C AND G (BETA-HEMOLYTIC)- OPPORTUNISTS- D. GROUP D ENTEROCOCCUS (NEW GENUS) (ALPHA, BETA OR GAMMA HEMOLYTIC)- OPPORTUNISTS- UTI'S, OCCASIONALLY SEPTICEMIA; NON-ENTEROCOCCUS- OPPORTUNIST- STREPTOCOCCUS BOVIS- IN BLOOD ASSOCIATED WITH COLON CARCINOMA E. STREPTOCOCCUS PNEUMONIAE "PNEUMOCOCCUSW- OPPORTUNIST- OTITIS MEDIA, PNEUMONIA "VIRIDANS" STREPTOCOCCI-
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. ANTIMICROBIAL AGENT SUSCEPTIBILITY TESTING F: "AN'TIBIO'1'1C"- ANTIMICROBIAL AGENT f MOST ARE USED AGAINST BACTERIA; ACT AT MANY R DIFFERENT SITES ON THE MICROBE (CELL WALL, CHROMOSOME, PROTEINS); THERE ARE A FEW FOR FUNGI(AMPH0TERICIN B; GRISEOFULVIN); ANTIVIRAL AGENTS BEING DEVELOPED (oAMANTADINE , E
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BIO361L1-1 - - - u/Lf . 3 w INFECTION - -&gt; D AMAGE TO...

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