lecture 3-4 - β-lactam moiety functional group of...

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Cytoplasmic (Inner) membrane
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Phospholipid structure X = -CH 2 -CH 2 -NH 3+ phosphatidyl ethanolamine (PE) (70%) -CH 2 -CH-CH 2 OH phoshatidyl glycerol (PG) (20%) OH
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Phosphatidylethanolamine Can be saturated or unsaturated
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Peptidoglycan structure NAG = N-acetylglucosamine NAM = N-acetylmuramic acid
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Gram Negative Gram Positive
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Gram Negative Gram Positive
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Penicillin G Targets peptidoglycan From Wikipedia: β-Lactam antibiotics work by inhibiting the formation of peptidoglycan cross-links in the bacterial cell wall . The
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Unformatted text preview: β-lactam moiety ( functional group ) of penicillin binds to the enzyme ( DD-transpeptidase ) that links the peptidoglycan molecules in bacteria, which weakens the cell wall of the bacterium (in other words, the antibiotic causes cytolysis or death due to osmotic pressure). In addition, the build-up of peptidoglycan precursors triggers the activation of bacterial cell wall hydrolases and autolysins, which further digest the bacteria's existing peptidoglycan...
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This note was uploaded on 06/10/2011 for the course BIO 339 taught by Professor Georgiou during the Fall '07 term at University of Texas.

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lecture 3-4 - β-lactam moiety functional group of...

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