02 DNA Replication and Repair

02 DNA Replication and Repair - DNA polymerase III to bind...

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Click to edit Master subtitle style  6/13/11 DNA Replication and Repair Reference: Chapter 4.3
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 6/13/11 Review
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 6/13/11
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 6/13/11
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 6/13/11 The double helix model proposed by Watson and  Crick lent itself very well to how DNA could  replicate. How do you think DNA would replicate? H bonds break DNA unzips Each strand acts as a template  to build complementary  base strand How Does DNA Replicate?
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 6/13/11 Proposed Models for DNA 
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 6/13/11 Meselson and Stahl’s Experiment
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 6/13/11 Labelling 5’ vs 3’ DNA Gyrase DNA Helicase Primase RNA Primer DNA Polymerase III Building Complementary 
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 6/13/11 What happens to the 5’ complementary strand? It starts with the RNA primer…  When the primer is removed there is no way for 
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Unformatted text preview: DNA polymerase III to bind nucleosides to it because there is no free 3 hydroxyl. Uh oh 6/13/11 Telomerase At the end of DNA strands there are repeated guanines and thymines which help form telemeres. 6/13/11 DNA Replication 6/13/11 Prokaryotes: DNA polymerase I, II, III Eukaryotes there are 5 types DNA Polymerase III double checks When mistakes occur the enzyme can act as an exonuclease Back tracks, removes, corrects 1 mistake every 100 000 nucleotides In humans, with our 6 billion base pairs in each diploid cell, that would amount to about 120,000 mistakes every time Replication and Repair...
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This note was uploaded on 06/12/2011 for the course BIOL CHEM 1000 taught by Professor Williampietro during the Spring '10 term at York University.

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02 DNA Replication and Repair - DNA polymerase III to bind...

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