04 Protein Synthesis The Details

04 Protein Synthesis The Details -...

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Transcription and Translation Reference: Chapters 5.3, 5.4, and  5.8 March 25, 2011
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Transcription: Initiation RNA polymerase  binds to the double  helical DNA at a  promoter region  Promoter:  sequence  of DNA that binds  RNA polymerase   upstream of a gene.   “Start Here” sign for  RNA polymerase Rich in As and Ts Most prokaryotic promoters the  sequence is not TATAAT.  The  sequences above are found in six E. coli  promoters
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Why is this area rich in As and Ts? Why is this area rich in As and Ts? RNA polymerase unwinds the double  helix by disrupting the hydrogen bonds AT has only 2 H bonds while GC has 3 H bonds Why do more work than you have to split DNA  strands? Template strand is exposed and RNA  polymerase can begin elongation
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Transcription: Elongation No primer needed  RNA polymerase builds mRNA 5’ to 3’ using  one DNA strand as a template ( template  strand) coding strand  is the DNA strand that is not  used for transcription.  identical sequence to the mRNA except U instead  of T continues to transcribe until a terminator  sequence
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Transcription: Termination Terminator sequence : a sequence of  bases at the end of a gene that signals the  RNA polymerase to stop transcribing RNA polymerase is released  free to bind to another promoter region mRNA strand is released and begins its  journey to exit the nucleus
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Post Transcriptional  Modifications The cytoplasm is a dangerous  environment, full of 
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This note was uploaded on 06/12/2011 for the course BIOL CHEM 1000 taught by Professor Williampietro during the Spring '10 term at York University.

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04 Protein Synthesis The Details -...

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