[生物书合集].Advances.in.Clinical.TBiostatisti

[生物书合集].Advances.in.Clinical.TBiostatisti

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Preface As the medical sciences rapidly advance, clinical trials biostatisticians and graduate students preparing for careers in clinical trials need to maintain knowledge of current methodology. Because the literature is so vast and journals are published so frequently, it is difficult to keep up with the rel- evant literature. The goal of this book is to summarize recent methodology for design and analysis of clinical trials arranged in standalone chapters. The book surveys anumber of aspects of contemporary clinical trials, ranging from early trials to complex modeling problems. Each chapter contains enough references to allow those interested to delve more deeply into an area. A basic knowledge of clinical trials is assumed, along with a good background in classical biostatistics. The chapters are at the level of journal articles in Biometrics
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Unformatted text preview: or Statistics in Medicine and are meant to be read by second- or third-year biostatistics graduate students, as well as by practicing biostatisticians. The book is arranged in three parts. The first consists of two chapters on the first trials undertaken in humans in the course of drug development (Phase I and II trials). The second and largest part is on randomized clinical trials, covering a variety of design and analysis topics. These include design of equivalence trials, adaptive schemes to change sample size during the course of a trial, design of clustered randomized trials, design and analysis of trials with multiple primary endpoints, a new method for survival analy-sis, and how to report a Bayesian randomized trial. The third section deals Copyright n 2004 by Marcel Dekker, Inc. All Rights Reserved....
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This note was uploaded on 06/13/2011 for the course PHYSICS 101 taught by Professor Shu during the Spring '11 term at FIU.

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