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Unformatted text preview: or Statistics in Medicine and are meant to be read by second or thirdyear biostatistics graduate students, as well as by practicing biostatisticians. The book is arranged in three parts. The ﬁrst consists of two chapters on the ﬁrst trials undertaken in humans in the course of drug development (Phase I and II trials). The second and largest part is on randomized clinical trials, covering a variety of design and analysis topics. These include design of equivalence trials, adaptive schemes to change sample size during the course of a trial, design of clustered randomized trials, design and analysis of trials with multiple primary endpoints, a new method for survival analysis, and how to report a Bayesian randomized trial. The third section deals Copyright n 2004 by Marcel Dekker, Inc. All Rights Reserved....
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This note was uploaded on 06/13/2011 for the course PHYSICS 101 taught by Professor Shu during the Spring '11 term at FIU.
 Spring '11
 Shu
 Physics, Current

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