[生物书合集].Advances.in.Clinical.TBiostatisti

[生物书合集].Advances.in.Clinical.TBiostatisti

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with more complex problems: including compliance in the assessment of treatment effects, the analysis of longitudinal data with missingness, and the particular problems that have arisen in AIDS clinical trials. Several of the chapters incorporate Bayesian methods, reflecting the recognition that these have become acceptable in what used to be a frequentist discipline. The 20 authors of this volume represent five countries and 10 insti- tutions. Many of the authors are well known internationally for their meth- odological contributions and have extensive experience in clinical trials practice as well as being methodologists. Each chapter gives real and rel- evant examples from the authors’ personal experiences, making use of a wide range of both treatment and prevention trials. The examples reflect work in a variety of fields of medicine, such as cardiovascular diseases, neu-
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Unformatted text preview: rological diseases, cancer, and AIDS. While it was often the clinical trial itself that gave rise to a question that required new methodology to answer, it is likely that the methods will nd applications in other medical elds. In this sense, the contributions are examples of ideal biostatistics, tran-scending the boundary between statistical theory and clinical trials prac-tice. I wish to express my deep appreciation to all the authors for their patience and collegiality and for their ne contributions and outstanding expositions. I also thank my husband for his constant encouragement and Marcel Dekker, Inc., for their continuing interest in this project. Nancy L. Geller Copyright n 2004 by Marcel Dekker, Inc. All Rights Reserved....
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