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Unformatted text preview: according to traditional, non-Bayesian methods (e.g., the up-and-down schemes described in Storer, 1989), an empiric, data-based definition is most often employed. Thus, the MTD is frequently taken to be the high- est dose utilized in the trial such that the percentage of patients manifesting DLT is equal to a specified level such as 33%. For example, patients are often treated in cohorts, usually consisting of three patients, with all patients in a cohort receiving the same dose. The dose is changed between successive cohorts according to a predetermined schedule typi- cally based on a so-called modified Fibonacci sequence (Von Hoff et al., 1984). The trial is terminated the first time at least some number of patients (generally 2 out of 6) treated at the same dose exhibit DLT. This dose level constitutes the MTD. The dose level recommended for phase II evaluation of ecacy is then taken to be either the MTD or one dose level below the MTD (Kramar et al., 1999). Although this serves as anbelow the MTD (Kramar et al....
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This note was uploaded on 06/13/2011 for the course PHYSICS 101 taught by Professor Shu during the Spring '11 term at FIU.
- Spring '11