[生物书合集].Advances.in.Clinical.TBiostatisti

[生物书合集].Advances.in.Clinical.TBiostatisti

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: and patient might benefit if updated assessments of the risk of toxicity were available during the trial. Both of these needs can be addressed within a Bayesian framework. In Sections 2.1 through 2.5 we present a description of selected Bayesian procedures developed for the specific case where toxicity is assessed on a binary scale (presence or absence of DLT), only a single agent is under investigation (the levels of any other agents being fixed) and no relevant pretreatment covariate information is available to tailor the dosing scheme to individual patient needs. We discuss extensions and modifications of the selected methods in Section 3. 2.1. Formulation of the Problem Dose level will be represented by the random variable X whose realization is denoted by x . For notational compactness, the same variable will be used for any formulation of dosage deemed appropriate. Thus, for example, X may represent some target drug exposure (e.g., AUC), the physical amount of agent in appropriate units (e.g., mg/mphysical amount of agent in appropriate units (e....
View Full Document

This note was uploaded on 06/13/2011 for the course PHYSICS 101 taught by Professor Shu during the Spring '11 term at FIU.

Ask a homework question - tutors are online