[生物书合集].Advances.in.Clinical.TBiostatisti

[生物书合集].Advances.in.Clinical.TBiostatisti

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Prob f DLT j Dose ¼ x tanh ð x Þþ 1 2 ! y : ð 4 Þ To facilitate comparisons between these two models, the hyperbolic tangent model can be rewritten as Prob DLT j Dose ¼ x fg ¼ exp ð 2 x Þ 1 þ exp ð 2 x Þ ! y which is consistent with the form given in Eq. (2) with h 0 = 0 and h 1 =2 assumed known. For exposition we consider the two-parameter logistic model given in (3). With this model the MTD is g ¼ ln ð u Þ± ln ð 1 ± u h 0 h 1 : An illustration of the model is shown in Figure 1 and properties of the model are given in (Johnson et al., 1995). Figure 1 Example of the logistic tolerance distribution used as a model for the
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