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Unformatted text preview: tion of k patients. Figure 2 shows the marginal posterior distribution of the MTD given the data shown in Table 1. 2.5. Loss Function As each patient is accrued to the trial, a decision must be made regarding the dose level that the patient is to receive. In a strict Bayesian setting, the decisions are made by minimizing the posterior expected loss associated with each permissible choice of dose level. To accomplish this, the set S of all permissible dose levels is speciﬁed and a loss function is chosen to quantify the cost or loss arising from the administration of each permissible dose under each possible value of N . The loss may be expressed in ﬁnancial terms, in terms of patient well-being, or in terms Copyright n 2004 by Marcel Dekker, Inc. All Rights Reserved....
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This note was uploaded on 06/13/2011 for the course PHYSICS 101 taught by Professor Shu during the Spring '11 term at FIU.
- Spring '11