[生物书合集].Advances.in.Clinical.TBiostatisti

[生物书合集].Advances.in.Clinical.TBiostatisti

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Unformatted text preview: 18 Babb and Rogatko Figure 2 Marginal posterior probability density function of the MTD of 5-FU given the data from all 12 patients treated in the 5-FU phase I trial. of the gain in scientific knowledge (Whitehead, 1997). Uncertainty about N is reflected through the posterior distribution and the expected loss associated with each permissible dose x is determined by averaging the loss attributed to x over the parameter space G Â V according to the posterior distribution C k. Thus, after k patients have been observed, the posterior expected loss associated with dose x 2 S is Z ELk ðxÞ ¼ Lðx; uÞ C kðuÞdu H and the next patient would receive the dose xkþ1 ¼ arg minfELk ðxÞg: x2S Copyright n 2004 by Marcel Dekker, Inc. All Rights Reserved. ...
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