[生物书合集].Advances.in.Clinical.TBiostatisti

[生物书合集].Advances.in.Clinical.TBiostatisti

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Unformatted text preview: target u , the extended version recommends using the dose with estimated probability of DLT nearest u * after the observation of a grade 4 toxicity. Hence, whenever a grade 3 or lower toxicity is observed, the extended CRM selects the dose level with estimated DLT probability nearest u , exactly as prescribed by standard CRM. Only upon observation of a grade 4 toxicity will the extended version select a dose different from (more precisely, less than or equal to) that recommended by CRM. As a result, use of the extended version of CRM will result in a more cautious escalation of dose level in the presence of severe toxicity. When toxicity can be modeled as a continuous variable Y the MTD is defined in terms of a threshold H representing a level of response deemed clinically unacceptable. For example, if it is desirable that Y not exceed H , then dose limiting toxicity corresponds to the event { Y z H } and the MTD is defined as the dose g such that Prob f Y z s j Dose g g u : The dose-toxicity model can be specified by assuming that the conditional...
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This note was uploaded on 06/13/2011 for the course PHYSICS 101 taught by Professor Shu during the Spring '11 term at FIU.

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