Acetylcholine_115_week3

Acetylcholine_115_week3 - Acetylcholine 115 to edit Master...

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Click to edit Master subtitle style Acetylcholine 115 Discussion Week 3
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Loewi’s Experiment
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Acetylcholine is involved in: Triggering motor movements at the NMJ, Learning (plasticity) Memory Induction of REM sleep Reward Arousal Selective attention Loss of cholinergic neurons:
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Acetylcholine Production Cholinergic neurons convert the amino acid choline into acetylcholine. The enzyme responsible is choline acetyltransferase. People think that taking more choline in their diet therefore enhances memory (by “boosting” acetylcholine). Unfortunately, that is not true because choline does not readily cross the blood
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Acetylcholine Breakdown Once acetylcholine has stimulated its receptors, it is broken down into a free amino acid (choline) by the enzyme acetylcholinesterase (AChE). AChE is inhibited (reversibly) by anti- Alzheimer’s drugs (like Aricept), in turn potentially correcting the partial loss of ACh that causes the disease.
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Acetylcholine_115_week3 - Acetylcholine 115 to edit Master...

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