PD_ASO_Spring11_Psych115_Wk4

PD_ASO_Spring11_Psych115_Wk4 - Genes The Brain Parkinsons...

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Parkinson’s disease and α -synuclein Spring 2011 Psych 115 Week 4
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What is Parkinson’s disease (PD) ? Progressive neurodegenerative disease characterized by loss of dopaminergic neurons in the substantia nigra pars compacta (SNPC) Symptoms: Resting tremors Rigidity in muscles Bradykinesia (slowed movement) Dementia in the later stages
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Nigrostriatal pathway Nigrostriatal pathway involves parts of the basal ganglia Striatum Substantia nigra pars compacta Under the influence of dopamine released from SNPC, the striatum regulates voluntary movement PD symptoms emerge when 50-80% of dopaminergic SNPC neurons have died
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Who gets PD? PD is the 2nd most common neurodegenerative disorder Both men and women, but more common in men Average age of onset = 61, but can be as early as 40 Only a small percentage (~10%) of PD cases are familial (inherited from parents) Majority of PD cases is sporadic (~90%)
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PD_ASO_Spring11_Psych115_Wk4 - Genes The Brain Parkinsons...

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