Psych_115_-_Genes_2

Psych_115_-_Genes_2 - GENES & THE BRAIN: PART 2...

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GENES & THE BRAIN: PART 2 Thursday, Week 3
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Serotonin
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Functions of Serotonin Sleep/wake cycle Feeding (hunger and satiety) Sexual function Mood
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Serotonin and Mood Once released, serotonin acts on a very large family of receptors (5-HT1-7, each with multiple subtypes; mostly metabotropic) After use, serotonin is inactivated by a specific serotonin transporter . Inhibition of this transporter prolongs the activity of serotonin within the synapse. This is the principle mechanism of action of a group of antidepressant drugs known as the specific serotonin reuptake inhibitors (SSRIs: fluoxetine [Prozac], paroxetine [Paxil], citalopram [Celexa], sertraline [Zoloft] and fluvoxamine [Luvox] ).
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Psychopharmacology The effects of SSRIs on mood disorders suggests that serotonin is involved in the pathogenesis of anxiety and/or depression Is that a reasonable conclusion? What other evidence might support this?
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Very much affected/modulated by genetic variation Gene variation  Neurochemical variation  Behavioral variation Neurochemistry
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A few points for review about genetic variation But first…
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Chromosomes Chromosome Pairs Two Chromosomes – Two Versions
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Chromosomes and Genes Each chromosome is a long double-stranded string of DNA (deoxyribonucleic acid) that contains the codes for many different GENES Genes are defined as segments of the genome that code for unique proteins Again, because you have a pair for each chromosome, you have two sets of instructions on how to make each protein (these sets of instructions are inherited from your two parents and may match or may be different)
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Genes Chunks of DNA that contain the “code” for making certain proteins Contain: 5’-Untranslated region (promoter) Coding region (exons) Introns (spliced out) 3’-Untranslated
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This note was uploaded on 06/13/2011 for the course PSYCH 115 taught by Professor Shaine during the Spring '07 term at UCLA.

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Psych_115_-_Genes_2 - GENES & THE BRAIN: PART 2...

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