Psych_115_-_Neurochemistry

Psych_115_-_Neurochemistry - PSYCH 115: PRINCIPLES OF...

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PSYCH 115: PRINCIPLES OF BEHAVIORAL NEUROSCIENCE Cellular neurophysiology and Neurochemistry April 4, 2011
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Action Potentials Move The initiation of the action potential at a single location spreads rapidly the event rapidly brings all the surrounding membrane to supra- threshold depolarization However, since Na + channels are inactivated during an action potential, the action potential can not move back from where it came
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Action Potential Propagation
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Action Potential Propagation This is where myelin (from oligodendrocytes) is important Passive propagation moves quickly but has a good chance of failure (by decay). Active propagation is more “sure fire” but is slow (jumping from channel to channel). Consequently, the speed of conduction of the action potential is accelerated when myelin insulates the axon, preventing “current leak” The action potential jumps between the “nodes of Ranvier”, the openings between the myelinated segments This is a process called “saltatory conduction”
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Ultra-micro-structure: the Synapse The synapse is the connection between an axon terminal and the dendrite (or soma) of another cell : the post- synaptic cell The two neurons are not physically in contact with one another There is a small space between
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The Spanish Anatomists Golgi Ramon y Cajal
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This is what they Saw…
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Neurons are Discrete Entities Ramon y Cajal looked at the cerebellum and found that there didn’t seem to be continuity between the pre- and post-synaptic entities – in essence, he guessed that neurons were “individuals” and not joined together (“anastomosed”) as was previously thought by some
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This is What None of Them Had Yet Seen… Neurons make very specialized near contacts with one another (say, at the connection between an axon and spine) called synapses
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synapse to mediate inter-cellular communication? Electricity?
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This note was uploaded on 06/13/2011 for the course PSYCH 115 taught by Professor Shaine during the Spring '07 term at UCLA.

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Psych_115_-_Neurochemistry - PSYCH 115: PRINCIPLES OF...

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