Psych_115_-_Neurophysiology

Psych_115_Neurophy - PSYCH 115 PRINCIPLES OF BEHAVIORAL NEUROSCIENCE Cellular neurophysiology Brain Cells and Networks We know that the nervous

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PSYCH 115: PRINCIPLES OF BEHAVIORAL NEUROSCIENCE Cellular neurophysiology March 31, 2011
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Brain Cells and Networks We know that the nervous system can be divided into GRAY MATTER (nuclei/ganglia: groupings of the dendrites and cell bodies of neurons) and WHITE MATTER (the fiber bundles or groupings of axons that connect neurons in different parts of the brain) We also know that neurons are relatively simple “computational devices” that only are capable of information processing when connected together into networks For today: let’s focus on single neurons and how they make some of their calculations…
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Intra-Cellular Transmission Neurons receive contacts from other cells onto their dendrites and transmit information to other cells via their axon terminals. How does information get integrated (from multiple inputs to the dendrites) and transmitted, especially
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Neurophysiology The membrane of neurons, like other cells, exhibits a voltage differential, with the inside of the cell being more negatively charged than the space immediately outside of the cell. Why?
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Neuronal Membrane The cell membrane, which is basically a double- layered sheet of fat, contains all the internals of the neuron Phospholipid bilayer
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Cytoplasm The cell is fluid- filled (cytosol) Many important factors are dissolved in the cytosol (proteins, chemical energy sources, charged molecules) The cell is also surrounded by fluid, but the membrane prevents the mixing of the internal and external fluids
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“At Rest” Ions (molecules that carry electrical charges) are differentially distributed outside and inside the cell
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“At Rest” Sodium, calcium (cations) and chloride ions (an anion) are in much higher concentration outside the cell Potassium ions (a cation) are in much higher concentration within the cell The intra-cellular milieu is also full of proteins which carry negative charges
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Forces on Molecules Two opposing forces influence the direction that ions will move across the membrane, if permitted to do so Diffusion : flow along the concentration gradient (panel A) Electrostatic forces: flow to
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Membrane Voltage Potential However, as shown here, the membrane is only semi-
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This note was uploaded on 06/13/2011 for the course PSYCH 115 taught by Professor Shaine during the Spring '07 term at UCLA.

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Psych_115_Neurophy - PSYCH 115 PRINCIPLES OF BEHAVIORAL NEUROSCIENCE Cellular neurophysiology Brain Cells and Networks We know that the nervous

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