Psych_115_-_Schizophrenia

Psych_115_-_Schizophrenia - PRINCIPLES OF BEHAVIORAL...

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Schizophrenia PRINCIPLES OF BEHAVIORAL NEUROSCIENCE
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What is Schizophrenia? “Schizm” or splintering of the “phren” or mind Not into different personalities as in Dissociative Identity Disorder Splintering of various mental faculties (thought, affect, social functioning, etc.) so that they are no longer coordinated Result is loss of touch with reality (psychosis)
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Components Thought Form (loosening of associations, incoherence, neologisms) Thought Content (delusions of persecution, grandeur, thought control) Attention and Perception (“over-attention”, hallucinations, voices) Affect, Motivation, Social Functioning (blunted or silly affect; anhedonia; social withdrawal)
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DSM-IV Criteria Either hears voices or has bizarre delusions, or has two or more of following, for 1-month or more c Delusions c Hallucinations c Formal thought disorder c Grossly disorganized behavior or catatonia c Flat or inappropriate affect Deterioration from a previous level of functioning in work, social relations, and/or self-care Continuous signs of the disturbance for at least 6 months, including prodromal/residual symptoms
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Differential Diagnosis Psychotic symptoms may also be present in mania and depression, but in those conditions, they never occur outside of a mood episode, and they are usually mood-congruent Psychotic symptoms may also occur in cases of drug abuse (amphetamines, PCP) and organic brain syndromes (dementia)
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Heterogeneity of Schizophrenia Symptoms - not all symptoms are present in every case & symptoms can differ across time within an individual Age at onset - differs markedly between males (late teens) and females (mid twenties) Premorbid functioning - for some, illness comes from ‘out of blue’, for others, insidious Course of illness - episodic versus chronic Long-term outcome - ‘rule of thirds’
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Genetic Epidemiology Sample Morbid Risk General population 1% First-degree relatives 10% Second-degree relatives 2-3% MZ co-twins ( r MZ = .82) 50% DZ co-twins ( r DZ = .40) 10% Offspring of 2 affected parents 36% Adopted away biological offspring 10%
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Schizotypal Personality Disorder Subthreshold symptoms (e.g., suspiciousness, odd
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This note was uploaded on 06/13/2011 for the course PSYCH 115 taught by Professor Shaine during the Spring '07 term at UCLA.

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Psych_115_-_Schizophrenia - PRINCIPLES OF BEHAVIORAL...

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