Psych_115_-_Synaptic_Plasticity

Psych_115_-_Synaptic_Plasticity - PRINCIPLES OF BEHAVIORAL...

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PRINCIPLES OF BEHAVIORAL NEUROSCIENCE Cellular mechanisms of learning and memory
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Medial Temporal Lobe and Memory Delayed-non-match-to- sample tests recognition Good way to test memory acquisition and retention Damage to the monkey MTL causes deficits of memory in monkeys This deficit includes the hippocampus and surrounding structures
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What Does the MTL Do, Specifically? These data suggest that the hippocampus, and surrounding MTL structures, are critical in the acquisition and temporary storage of memories (that’s why HM’s memory is intact for long distant memories) Eventually, the MTL must pass those memories onto a different part of the brain for permanent storage
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Cellular basis of learning and memory Experience-dependent modifications in behavior must relate to experience-dependent changes in the brain Working memory is easy: memory is related to activity profiles of neurons in prefrontal cortex But what about life-long (or long-lasting) memories? It is not possible that life-long (or long-lasting) cell firing underlies the retention of those memories
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Clues from Differential Rearing Experiments Standard condition: rats housed in triads Impoverished condition: rats singly housed Enriched condition: lots of toys
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Experience Changes the Brain Enriched lives lead to: Better learning and problem-solving skills Higher levels of neurotransmitters Heavier cerebral cortex Thicker cortex Altered gene expression Much more rich neuronal communication, evidenced by more extensive dendritic trees (arborizations) and higher numbers of synaptic connections onto those trees
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Simple Memories: Simple Brains The discovery of the cellular
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Psych_115_-_Synaptic_Plasticity - PRINCIPLES OF BEHAVIORAL...

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