4_ReplicationFork

Lehninger Principles of Biochemistry

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Lecture 4 DNA Replication Semi-conservative Semi-discontinuous Bidirectional DNA replication:
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Reading 25 | pp. 975-990 © 2009 W. H. Freeman and Company
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Replication of Genetic Code It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material Watson and Crick, Nature,1953 Strand separation occurs first Each strand serves as a template for the synthesis of a new strand Synthesis is catalyzed by enzymes known as DNA polymerases Newly made DNA molecule has one daughter strand and one parent strand.
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Is Replication Semiconservative? Conservative Semiconservative
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The Meselson-Stahl experiment was about the origin of the two strands in each of the daughter genomes Cells were grown on a medium containing only 15 N isotope until all their DNA became fully 15 N labeled Cells were then switched to 14 N medium and allowed to divide once
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4_ReplicationFork - Lecture 4 DNA Replication DNA...

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